To Sleep is a science fiction novel told through the journal of Karen Miller, a nurse and pre-med student from Philadelphia. The journal begins the night three alien ships appear above Earth. When Karen awakes, she is told Earth was destroyed by a space phenomenon called the Rift; that she is to be the leader of a small group of women tasked with assisting their alien rescuers in awakening the four billion or so surviving humans who are in cryogenic suspension; oh, and that Earth was gone and only half of the human species survived.

Each time Karen goes to sleep, she doesn't know exactly what it will be like when she wakens. The line between what is real and what is not real becomes blurred until Karen and the other women can only trust each other. When reality is finally defined, the six of them learn truths that will forever change not just themselves, but every genetic homosexual on Earth.