Uveitis is a potentially blinding inflammatory disease that presents one of the most serious and complicated therapeutic challenges in the field of ophthalmology. During the last decade, the therapeutic armamentarium of the uveitis specialist has enormously expanded. Novel biologic agents and intraocular therapy are becoming a valuable alternative treatment to control ocular inflammatory diseases and inflammatory macular edema — the most important cause of visual loss in patients with uveitis. This publication is designed to bring together the principles of therapy of patients with noninfectious uveitis and the most recent therapeutic options available. General ophthalmologists, uveitis specialists as well as residents will find it a useful update on the latest innovative treatment options for patients with noninfectious uveitis.