This book presents a case for engagement between the sciences and the humanities. The author, a professional chemist, seeks to demonstrate that the connections between those fields of intellectual activity are far more significant than anything that separates them. The book combines a historical survey of the relationships between science and literature with a number of case studies that examine specific scientific episodes—several drawn from the author's own research—juxtaposed with a variety of literary works spanning a wide range of period and genre—Dante to detective fiction, War and Peace to White Teeth—to elicit their common themes. The work argues for an empirical, non-theory-based approach, one that is closely analogous to connectionist models of brain development and function, and that can appeal to general readers, as well as to literary scholars and practicing scientists, who are open to the idea that literature and science should not be compartmentalized.