This novel had a profound effect on attitudes toward African Americans and slavery in the United States, so much in the latter case that the novel intensified the sectional conflict leading to the American Civil War.
Uncle Tom's Cabin was the best-selling novel of the 19th century, and the second best-selling book of that century, following the Bible. It is credited with helping fuel the abolitionist cause in the 1850s. In the first year after it was published, 300,000 copies of the book were sold in the United States alone. 
This is probably one of the most beautiful digital version ever made of this story, containing over 90 gorgeous illustrations.