Apraxia is a term used to denote a disorder in the performance of limb, verbal and oral non-verbal gestures, with often preserved ability to perform these same gestures outside the clinical setting in the appropriate situation or environment. Over the past century and particularly in the past four decades, a great deal of research has focused on understanding the nature of this complex disorder.This book is a review of current approaches to the study of apraxia and related action sequencing disorders as well as an examination of the mechanisms thought to underly these disorders. Neuropathological processes associated with apraxia are evaluated and principles of motor control, handedness and bimanual coordination are considered as they relate to the study of apractic disorders.