This book is a collection of selected papers presented at the First International Conference on Industrial IoT, Big Data and Supply Chain (IIoTBDSC), held as an online conference due to COVID-19 (initially to be held in Macao, Special Administration Region (SAR) of China), during September 15–17, 2020. It includes novel and innovative work from experts, practitioners, scientists and decision-makers from academia and industry. It brings multi-disciplines together on IIoT, data science, cloud computing, software engineering approaches to design, development, testing and quality of products and services.