This issue of Emerging Cancer Therapeutics provides a comprehensive review for practitioners on the current status of renal cancer treatment. Renal cancer treatment has undergone major changes over the course of the past few years and Renal Cancer addresses current best practices in the light of the most recent evidence. All of the chapters are written by international experts in the field, address the common clinical scenarios in renal cancer and are multidisciplinary in scope covering surgical, medical, and radiation therapy. Chapters examining emerging and novel therapeutic targets, the management of both CNS, and skeletal metastases in renal cancer round out the coverage.