This issue of Radiation Medicine Rounds examines the latest advances in the use of radiation medicine in treatment of prostate cancer Prostate cancer is the most common cancer in males and radiation therapy is a major tool in the management of the disease. This issue of Radiation Medicine Rounds includes reviews of all major recent advances in treatment of favorable, intermediate and high-risk prostate cancer as well as newer modalities such as brachytherapy, stereotactic body radiation therapy, and proton beam radiotherapy. Articles also review current knowledge in the areas of new biomarkers, risk stratification, and risk stratification. This issue of RMR will provide the practitioner with a full current overview of the present best practices and recent research in management of this complex and challenging disease.