The Anthropocene concept draws attention to the various forms of entanglement of social, political, ecological, biological and geological processes at multiple spatial and temporal scales. The ensuing complexity and ambiguity create manifold challenges to widely established theories, methodologies, epistemologies, and ontologies. The contributions to this volume engage with conceptual issues of scale in the Anthropocene with a focus on mediated representation and narrative. They are centered around the themes of scale and time, scale and the non-human, and scale and space. The volume presents an interdisciplinary dialogue between sociology, geography, political sciences, history, and literary, cultural and media studies. Together, they contribute to current debates on the (re-)imagining of forms of human responsibility that meet the challenges created by humanity entering an age of scalar complexity.