This book gathers selected papers presented at the International Conference on Machine Intelligence and Soft Computing (ICMISC 2020), held jointly by Vignan's Institute of Information Technology, Visakhapatnam, India and VFSTR Deemed to be University, Guntur, AP, India during 03-04 September 2020. Topics covered in the book include the artificial neural networks and fuzzy logic, cloud computing, evolutionary algorithms and computation, machine learning, metaheuristics and swarm intelligence, neuro-fuzzy system, soft computing and decision support systems, soft computing applications in actuarial science, soft computing for database deadlock resolution, soft computing methods in engineering, and support vector machine.