When the newly formed WHISP task force is called in to investigate a kidnapping and possible bioterrorism attack, NYPD Detective Sylvia Harbinger finds herself the middle woman between the NYPD and an extremist anti-WHISP organization, exposed to a WHISP virus, and having lengthy conversations with her own recently formed WHISP. Or is she only talking to herself?

With Ben and Lincoln backing her in the task force laboratory, she races to find the kidnapping victims and a cure, yet the terrorists always seem to keep one step ahead. Sylvia's running out of leads and out of time, but giving up isn't an option. One of the lives she saves may be her own.