Maxwell and Karina, twins who are the cure to a disease which is ravaging the country, find themselves journeying to the distant locale of Collern City in search of their missing mother. Meeting strange allies and dealing with dangerous enemies, they must learn to navigate the treacherous streets and discover more about what is going on behind the scenes in both the gated community and outside of it. Meanwhile, their guardian and friend, Lex, struggles to deal with his family's desires. He finds himself caught between his own wish to flee his home, never to return. and the wish of his brother, Caym, who desperately wants him to stay.