Two men meet in medical school and discover a shared love of rough sex, abduction, and cruelty. Together they develop a game. They find women eager to earn a few extra dollars and sign them up for a "study." These women become the hunted. Hope, a grad student trying to make her own way, becomes the latest victim in their games. Through abduction, mutilations, and forced breeding, will she come out alive, or will she become one of the hunted?