The immortality of the captive Manji is being sorely tested, as the horrifying experiments commanded by Habaki Kagimura in the dungeons below Edo castle continue. One of Kagimura's doctors, Ayame Burando, has already gone half-mad, tormented by the sickening mutilations intended to unlock the secret of passing Manji's amazing regenerative powers to others, and Burando's replacements have upped the ante with their utter incompetence. Meanwhile, Manji's charge, Rin, is desperately trying to find him, but Edo's brutal police are on her trail, and the race is on for Rin to free her immortal bodyguard before she joins him behind bars!