Volume 42 presents an in-depth review on Alzheimer's Disease as well as a look at several transcription factors. - Clinical features of stroke and the current stasis of stroke therapy - Alzheimers Disease—pathology, pathological proteins, etiology, pathogenesis, neurotransmitter alterations, and treatment strategies - An examination of the regulation of AP-1 and related transcription factors and their role in brain injury and drug abuse-related behavior - Emerging roles of the transcription factor NF(B - Recent advances about the nature of alterations in ion channel structure or function which may be responsible for epileptogenesis - An integrated model accounting for the multiple mechanisms involved in the posttranslational regulation of glutamate ionotroic receptors - Genetic mutation and the Glycine Receptor