This book gathers high-quality papers presented at the First International Conference of Advanced Computing and Informatics (ICACIn 2020), held in Casablanca, Morocco, on April 12–13, 2020. It covers a range of topics, including artificial intelligence technologies and applications, big data analytics, smart computing, smart cities, Internet of things (IoT), data communication, cloud computing,  machine learning algorithms, data stream management and analytics, deep learning, data mining applications, information retrieval, cloud computing platforms, parallel processing, natural language processing, predictive analytics, knowledge management approaches, information security, security in IoT, big data and cloud computing, high-performance computing and computational informatics.