Trelawney Hope, secretary for European Affairs, reaches out to Holmes. A very important letter was stolen from Hope's safe and he wants Holmes to track it down. The letter's content was of political importance and the three main suspects of Holmes are international secret agents. However one of them, Eduardo Lucas, was found murdered. Is there some connection between both crimes and will Holmes connect the dots? "The Adventure of the Second Stain" is a part of "The Return of Sherlock Holmes".