Lifelong friends facing the future after cancer, Kathy, Eileen, and Charlotte are each dealing with complex family relationships and emotional issues. Kathy's husband is a serial cheater. Eileen's mother keeps telling her she's not wonderful like her sister. Charlotte still aches from losses of years ago. This is their second chance, the moment when they can make important life changes before it's too late.

As they take up the challenge of finding hidden treasures at a family beach house in Cape May and back home in the affluent Washington, DC, suburb of Bethesda, Maryland, these best friends discover shocking family secrets as well as new strengths in themselves. Their story entwines with those of Steve, an old friend with a mystery he's trying to solve, and much younger Brian, whose army career has been his whole focus until he faces a life-changing dilemma.

What must each of them give up in order to take the next bold step to happiness?