Comedian Channing Hayes survived a tragic auto accident that claimed the life of his fiancée, Lauren. Physically and emotionally scarred, he's put his performing career on hold, resigned to getting laughs vicariously as co-owner of The Last Laff Comedy Club. There, he instructs Lauren's sister Heather in the fine art of stand-up.

When Heather skips out on her set during the club's comedy showcase, Channing searches for his AWOL protégée. Then Heather's ex-lovers start turning up dead—and Channing must fight to keep Heather from being the next hit in this deadly line-up.