In a lawless American West transformed by the Second Civil War, part-time bounty huntresses Ramona del Toro and Jo Lilly take a job: find and capture a mysterious woman named Cottonmouth, accused of murdering an innocent man. As they track her through northern Arizona, southern Utah, Colorado, and New Mexico, Ramona and Jo encounter colorful people who can only point them in Cottonmouth's direction. When Jo and Ramona finally catch up to Cottonmouth, she reveals the truth. Will the bounty huntresses join their target or trade her for a bag of cash?