Within a charming, if dilapidated, Brooklyn brownstone live a family of sorts: beautiful agoraphobe Adeleine; Thomas, an artist who has shut away his materials in the wake of a stroke; Edward, a cynical stand-up comedian and Paulie, a young man with William's Syndrome. Brought together by ageing landlady Edith, the tenants all live safely in tune with each other. But when their home is suddenly and violently threatened, they are shocked into action.