Brother Nicholas, a monk in medieval Germany, found himself rejected and isolated: scorned by the Jewish community who raised him because of his conversion to Christianity, and distrusted by his fellow churchmen as a former Jew, whose faith is always subject to doubt and suspicion. He finally flees to a remote castle, in a distant, impoverished land, to serve as the new confessor to the mysterious Lady Catherine, who has ruled the fortress as a recluse ever since her husband was mysteriously murdered in his bed.

There he will discover the unholy and occult practices that have kept the Lady Catherine eternally young and beautiful, and which will test his own faith. And even more wondrous is the castle's prisoner, whose blood is drawn for her Ladyship's dark rites: Cartaphilus, the legendary Wandering Jew cursed by Jesus Christ on the Via Dolorosa to roam the Earth forever with no rest for his tormented soul.

A meditation on faith and betrayal, The Vampire and The Wandering Jew explores one man's agonizing attempt to follow his spiritual calling and the divine will in the face of petty human resentments and deeper, more insidious evil.