This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods. - Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist