Columbia, SC. Forty-something ER physician Sam Buchanan has gotten too comfortable in the lap of luxury. But when he discovers his wife is having an affair, he's ashamed to realize he's ended up a distant, selfish alcoholic. Vowing to redeem himself, he quits cold turkey, sells his possessions, and takes a job at a hospital in New Orleans.

Finding fresh opportunities and potential love, Sam reinvents himself in the Big Easy's Uptown district. But news of the death of a friend he could have saved back in South Carolina shatters his confidence and knocks him off the wagon. And when a meddling acquaintance threatens his budding romance, Sam fears his demons may be too strong to defeat.

Can Sam kiss the bottle goodbye forever and finally become the person he wants to be?