Bringing together a collection of studies we hope to further an understanding of the extra-medical use of prescription drugs in a variety of different settings and locations. Our aim is to situate prescription drugs within a wider frame, where it connects with (currently) illegal drugs and as a component in the careers of drug consumers and traders. Several authors therefore highlight how prescription drugs can complement, support, and enhance other types of drug use. This relates to their legal status and availability, as well as the complex decision making that is involved in selecting from a wide range of prescription drugs – pain relievers, tranquilizers, stimulants, and sedatives. Users have to make considered choices that balance complex arrays of factors including drug effect, potential harm to health and liberty, and how drug use and risk can be integrated into lifestyles.