Since the first case of sickle cell disease was described in 1910, several efforts have been made to improve its management. However, it remains the leading scourge of our times, with a high level of morbidity and mortality in Sub-Saharan Africa, the Middle East and India. There have been few efforts by academia in developing countries towards contributing to in-depth knowledge of sickle cell disease. This volume rectifies this by providing a comprehensive review of sickle cell disease from a multidisciplinary point of view. Bringing together a number of experts in the field, the text highlights details of what is known and areas in which future work and advances are needed. The contributions contain comprehensive information on all aspects of the disease, and provides a solid foundation for future studies.