Asher Benson has once again fled to a secluded cabin in the mountains outside of the sleepy town of Arthur's Creek, West Virginia. Government agents surround him day and night, blanketing his entire life in constant surveillance under the guise of keeping him safe.

That facade is shattered when every cell phone in Arthur's Creek rings simultaneously. Anyone who answers the call is driven into a violent, psychotic madness that turns the entire town into a slaughterhouse.

And Ash is caught in the middle of it all.