The goal of the sixth volume of the ITI Treatment Guide series is to provide clinical recommendations for implant-supported prosthodontic treatments in patients with multiple missing adjacent teeth in the esthetic zone. It summarizes the results and consensus statements of the 3rd and 4th ITI Consensus Conferences and contains a review of current evidence regarding these often complex treatments. Clinical recommendations for treatment alternatives and procedures are based as much as possible on existing scientific and clinical evidence including the experiences and suggestions of many seasoned clinicians within the ITI and outside. Special emphasis is given to the preoperative evaluation, treatment planning, and assessment of risk factors for these – often complex – indications. Surgical and prosthodontic procedures are presented with detailed descriptions and illustrations followed by a number of step-by-step clinical case presentations. Complications of various etiologies are also highlighted and suggestions are made on how to avoid them. A number of clinical cases documenting on various complications and their treatment complete this volume of the ITI Treatment Guide. The ITI Treatment Guide series is a compendium of evidence-based implanttherapy techniques in daily practice. Written by renowned clinicians and supported by contributions from expert practitioners, the ITI Treatment Guides provide a comprehensive overview of various therapeutic options. The management of different clinical situations is discussed with an emphasis on sound diagnostics, evidence-based treatment concepts, and predictable treatment outcomes with minimal risk to the patient.