As America reels from the bizarre presidential assassination committed by a child, seven men are abducted from their normal lives and delivered to a secret government facility. Each man has his own career, his own specialty. All are identical in appearance. The seven strangers were grown—- unwitting human clones—-as part of a project called 7th Son.

The government now wants something from these "John Michael Smiths." They share the flesh as well as the implanted memories of the psychopath responsible for the president's murder. The killer has bigger plans, and only these seven have the unique qualifications to track and stop him. But when their progenitor makes the battle personal, it becomes clear he may know the seven better than they know themselves.