Following the devastation of World War III, nuclear radiation has spawned magic, ranging from nuisance koppa oni plaguing the Golden Gate to masters of the elements. It falls to the FBI's supernatural quads and their supervisors to protect those who can't protect themselves.

But when a mysterious force storms through a busy shopping center and fells everyone in its wake, Olivia Abrams and her team of special ops must find who is behind the attack and why before the entirety of San Francisco succumbs to its powers.