Opioids are pain relievers that include legal drugs like morphine, fentanyl, and oxycodone and illegal drugs like heroin. In 2017, the U.S. Department of Health and Human Services declared the opioid epidemic a public health crisis after 42,249 people in the United States died of opioid overdoses in 2016. Opioid prescription has been on the rise since the 1990s, when pharmaceutical companies asserted that the pain relievers were not addictive, though the tragic consequences have proven otherwise. This volume explores the history of the opioid crisis and solutions that have been proposed to fight this increasingly deadly epidemic.