This fourth volume of the ITI Treatment Guide series presents implant therapy approaches and procedures in edentulous patients with a special focus on loading protocols. After discussing the current evidence base in the literature and a summary of the most recent relevant ITI Consensus Statements it proceeds to guide readers through the entire treatment process. Beginning with a chapter on preoperative assessment and prosthetic planning, different treatment options for the edentulous arch are presented. They are complemented by a separate chapter on the selection of the appropriate loading protocol considering risk evaluation and the complexity of the possible treatment options. Various procedures are illustrated with patient case studies. Detailed illustrations serve to clarify potential ambiguities, and complications are addressed to avert the most common problems in clinical practice. The ITI Treatment Guide series, a unique compendium of evidence-based treatment methods in implant dentistry in daily practice, written by renowned clinicians, provides a comprehensive overview of various therapeutic options. Using an illustrated step-by-step approach, the ITI Treatment Guide shows practitioners how to manage different clinical situations, with the emphasis on sound diagnostics, evidence-based treatment concepts, and predictable treatment outcomes. Implant dentistry has become a standard option for the rehabilitation of fully and partially edentulous patients.