The book includes high-quality papers presented at the 4th International Conference on Smart Learning Ecosystems and Regional Development at Università Roma Tor Vergata, Italy, from 22 to 24 May, 2019. Providing insights into the relevance of smart learning ecosystems (schools, campuses, the workplace, informal learning contexts, etc.) for regional development and social innovation, it also discusses how citizens' involvement with smart ecosystems can be increased and made more effective.