Carmine Locascio was in trouble with authorities by December 1940. He was charged with his brother Peter for illegal liquor/bootlegging. Later in his life he was a lynchpin in an international dope syndicate run by exiled mobster Charle "Lucky" Luciano. Luciano started a narcotics syndicate that was run from Naples, Italy. An integral part of the Allied/anti-Nazi World War II resistance, Luciano was deported in the aftermath of the war. Locascio was active in the Long Island/Westchester County portion of the international ring. In 1960 and again in 1961 he was apprehended for heroin smuggling.