The Oxford Handbook of Mesoamerican Archaeology provides a current and comprehensive guide to the recent and on-going archaeology of Mesoamerica. Though the emphasis is on prehispanic societies, this Handbook also includes coverage of important new work by archaeologists on the Colonial and Republican periods. Unique among recent works, the text brings together in a single volume article-length regional syntheses and topical overviews written by active scholars in the field of Mesoamerican archaeology. The first section of the Handbook provides an overview of recent history and trends of Mesoamerica and articles on national archaeology programs and practice in Central America and Mexico written by archaeologists from these countries. These are followed by regional syntheses organized by time period, beginning with early hunter-gatherer societies and the first farmers of Mesoamerica and concluding with a discussion of the Spanish Conquest and frontiers and peripheries of Mesoamerica. Topical and comparative articles comprise the remainder of Handbook. They cover important dimensions of prehispanic societies—from ecology, economy, and environment to social and political relations—and discuss significant methodological contributions, such as geo-chemical source studies, as well as new theories and diverse theoretical perspectives. The Handbook concludes with a section on the archaeology of the Spanish conquest and the Colonial and Republican periods to connect the prehispanic, proto-historic, and historic periods. This volume will be a must-read for students and professional archaeologists, as well as other scholars including historians, art historians, geographers, and ethnographers with an interest in Mesoamerica.