Naming Darwin's Black Box to the National Review's list of the 100 most important nonfiction works of the twentieth century, George Gilder wrote that it "overthrows Darwin at the end of the twentieth century in the same way that quantum theory overthrew Newton at the beginning."

Discussing the book in the New Yorker in May 2005, H. Allen Orr said of Behe, "he is the most prominent of the small circle of scientists working on intelligent design, and his arguments are by far the best known." From one end of the spectrum to the other, Darwin's Black Box has established itself as the key text in the Intelligent Design movement—the one argument that must be addressed in order to determine whether Darwinian evolution is sufficient to explain life as we know it, or not.
For this edition, Behe has written a major new Afterword tracing the state of the debate in the decade since it began. It is his first major new statement on the subject and will be welcomed by the thousands who wish to continue this intense debate.