Judas Coon Seols is a simple family man with a strong faith in God and a new purpose as deacon of a church founded by his acquaintances, Sister Patricia and Father O'Brien.

Sister Patricia is a forensic pathologist who, along with Father O'Brien, has finally determined her identity as a practicing Christian. As she carefully examines her most recent corpse tattooed with Michelangelo's The Last Judgement, Judas looks on as both are filled with questions, especially since this is just one of many recent strange deaths. Meanwhile as two detectives begin an investigation into the murders, they are less than successful—until they stumble upon Sister Patricia's possible involvement. While attempting to fully understand the killer's motive, the detectives must overcome several obstacles as those involved are forced to trust not just themselves, but also their individual beliefs. Unfortunately, as they are all about to discover, people are not always who they seem.

The Damascus Road chronicles a perplexing series of murders as a pathologist, church deacon, and two detectives become immersed in a battle of good versus evil.