Cheyenne, 1888. Ezra McPherson is a gunfighter who cannot escape the past, and Luke Tisdale is a young doctor whose brother has been murdered. Marcus Stokesbury and Eloise Endicott are journalists who are intrigued by the mystery surrounding Ezra. Together with Richard Swearingen, a cattle baron who seeks to establish a kingdom in Wyoming, and Andrew Swearingen, a man who has killed but who is now willing to take an extraordinary step to prevent bloodshed, they all become embroiled in a story of love, greed, betrayal and sacrifice.