Searching for his estranged sister who is homesteading in Dakota, Scottish clergyman Guthrie Gunn is bushwhacked, and subsequently discovers that the same outlaws had previously killed all but one of his living relatives. Rescued by the Lakota, he finds his nephew living among them. Finding new faith after undergoing a Vision Quest, which shows him that his destiny is to seek out the villain, he embarks on a search for the wrongdoers, preaching his own quirky brand of religion along the way. After seven years, he finds his way to Misery, Montana, where his enemies are now despotic lawmen. Gunn is joined by a motley band of avengers - including a Lakota tribesman, a reformed outlaw, a dime novelist, and two of the most notorious outlaws in the West - who will need all their diverse skills to stand a chance against the maniacal sheriff and his ruthless deputies.