"He's changed!" Professor Challenger cries out.

"Watson is no longer...Watson!"

"No!" Holmes replies.

Harry Houdini shakes his head. "Holmes, there is very much the possibility that you have lost your friend...forever!"

"I will not accept that!" Holmes shoots back. "Never!"

The war that began in the Case of the Risen continues, but now it has struck even into the heart of Baker Street.

Into the very heart of Holmes himself.

How will he and his friends deal with the spreading infection that has spread malicously throughout London and soon the very world itself?