BENEATH THE DIM LIGHT OF A FULL MOON, MADNESS REIGNS...

As night descends on Cincinnati, the city braces for hell on earth: The populace mutates into huge, snarling monsters that devour everyone they see and act upon their most base desires. Planes fall from the sky. Highways are clogged with abandoned cars, and buildings explode and topple. The city burns.

And when daylight comes at last, the same monsters return to human form, many driven insane by atrocities committed against friends and families.

Only four survivors are immune to the metamorphosis: a smooth-talking thief who lives by the code of the Old West; a bank teller who's put her past behind her; a wealthy, disillusioned housewife; and a desperate teenaged runaway. Together they form an unlikely quartet that must find a way to stop the apocalypse before the next full moon.