Dr. Rebecca Davis is an OBGYN on a forced vacation due to a sixty-day suspension from her job at a New York City hospital. Aggravated and upset, not only over the issues at work but a failed and complicated relationship, she takes an impulsive trip to a rural town and gets drunk, waking up the next day in an unfamiliar motel room. Here, she meets the motel's charming and attractive owner, Colleen MacDonald.

Hope Harris is in mourning over her wife's death, but she is determined to continue managing her farm, taking care of her kids and their growing pains, and living life every day. A sudden accident changes everything and Hope finds it necessary to rely on others to help her. Veronica Saunders, a physical therapist assigned to her, sparks feelings she has not experienced since Hannah's death.

Rebecca, as she is assisting the local doctor with his caseload, is faced with troubles from the past that threaten her new love, and Hope, recovering from her injuries, is shocked when revelations about her teenaged sons come to light.

Can these two women find love amidst their increasingly tumultuous lives? Are the lovers they choose the "ones"? Find out in The Doctor Is In, River's Bank, a small town full of big love.