Carefree and irrepressible, Casey Wilde has spent her life running. Running from love, running from responsibility, and running from commitment. Megan Woodson, Casey's best friend, has spent her life building security with a long-term partner and a well-paying, highly respected position in the best ad agency in Memphis. Ben Stagg is a man who has lost everything, including the desire to live. And Brilliant Wilson is a photographer who can't quite figure out why she keeps dating women who don't love her. Faced with painful and pressing decisions, the group is forced to confront their own life choices.

When their worlds collide and everything starts to fall apart, these friends must learn that the only important decision is the one to follow their hearts.