A "searingly honest and riveting" (Colm Tóibín) memoir interweaving the author's descent into depression with a medical and cultural history of the illness.

At the age of twenty-seven, Mary Cregan gives birth to her first child, a daughter she names Anna. But it's apparent that something is terribly wrong, and two days later, Anna dies—plunging Cregan into suicidal despair. Decades later, sustained by her work, a second marriage, and a son, Cregan reflects on this pivotal experience and attempts to make sense of it. She weaves together literature and research with details from her own ordeal—and the still-visible scar of her suicide attempt—while also considering her life as part of the larger history of our understanding of depression.