The destruction of the Earth by alien antimatter at a secret laboratory can only be prevented through the genius of Professor Quagmire. The problem being that he is confined to a secret insane asylum for scientists who have overtaxed their minds and are now outright crazy. Doctor Lynda Gray, medic at the secret lab has the unenviable task of retrieving him from Roads End Institution and working with him to save the world. All the while, she struggles with personal demons, the death of her husband and unforgiving daughter.