Tyson, a sister's love be limitless is a fictional whodunit written in the voice of a 27-year-old, southern "colored" woman, Leonia Gillette. She and her big brother, Tyson, come north to escape a drunken father who tried to rape her. They settle in Harlem in 1927 during the Harlem Renaissance and just before the Great Depression.
In 1932, somebody castrates, then murders Tyson in a Harlem alleyway, supposedly as revenge for his unpaid gambling debts. Leonia doesn't believe the police report and decides to investigate her brother's death. Along the way to uncovering Tyson's killer, Leonia introduces us to a cast of characters—good, bad, and very bad— found only in the Harlem of the thirties.