This book introduces advanced methods of computational and information systems allowing readers to better understand the state-of-the-art design and implementation technology needed to maintain and enhance the safe operation of nuclear power plants. The subjects dealt with in the book are (i) Full digital instrumentation and control systems and human–machine interface technologies (ii) Risk monitoring methods for large and complex plants (iii) Condition monitors for plant components (iv) Virtual and augmented reality for nuclear power plants and (v) Software reliability verification and validation for nuclear power plants. The target readers of this book are Ph.D. students, researchers and engineers in the field of nuclear power engineering.