To keep the bank from repossessing her eighteen-wheeler and putting her and her daughter on the street, trucker Loretta Brennan takes a dangerous route to Wyoming with a winter storm approaching. She worries if she can make the deadline and navigate the icy roads since her driving partner husband died in an accident the year before.

At a truck stop, Loretta meets handsome hitchhiker Sam Emerson, who helps her out of a bind. She feels compelled to return the favor and offers him a ride to Cheyenne. Blizzards, a series of trucker murders, and a sinister truck haunt them along their route. They grow close despite Loretta's fear that Sam may be aligned with the killer. Is Sam a good man down on his luck or is she falling in love with a murderer?