What happens after the famous private detective Sherlock Holmes dies fighting evil Professor Moriarty at the Reichenbach Falls? It takes time for the news to reach the general public, so desperate people still come to seek his help at 221b Baker Street. Holmes' landlady, the invincible Mrs. Hudson, and her Cockney maid Fanny-Annie Grubbins, take over his work to become The Detective Ladies of Baker Street.In their first case, an over sensitive Mrs. Moonstone calls to say her husband is missing. And later her jewellery. And finally her children's beautiful governess. An obvious case of marital deception. However Mrs Hudson and Fanny-Annie soon discover nothing is so simple in the world of private detectives, especially female ones in a Victorian male-dominated society. But with genuine compassion for those in need and a bloody-minded dedication to duty, they crack on regardless. And encounter mystery and murder and possibly a budding romance before they eventually triumph. In the novel we are introduced to regulars in the series: starchy Miss Prim from next door at 221a Baker Street, and stern but fair Inspector Trengrove of Scotland Yard.