Gambini is back! Hot on the heels of rescuing his cousin Bill and Bill's friend Stan from an Alabama electric chair, our wildly inappropriate hero, Vincent Gambini heads home to Brooklyn where he attempts to establish a successful law career. Meanwhile, Lisa aches to have a wedding band placed around her finger and her biological clock is still ticking away like mad.

In the course of building his practice, Vinny is reunited with Joe, his walking, talking embarrassment of a brother and his dear old friend Judge Henry Molloy, who refers him the mother of all capital murder cases. Theresa Cototi is young and pretty but far from innocent. Her boyfriend has just been scraped off the pavement after taking a dive from eight stories up and she's going to trial, charged with murder one. Aided by Lisa and a ragtag team of misfits, Vinny defends his client against overwhelming odds. In the balance hangs the life of a woman he believes to be innocent. Or is she? Yes, Vinny may have finally won his first case but his and Lisa's story is far from over.